Agmatine Sulfate (아그만틴)

섭취
하루 1mg

긍정
우울증, 기억 등에 큰 도움을 줄 수 있음.
우울감에 특히 큰 도움을 줄 수 있음.
nmda 수용체 정상화에 역할을 한다고 함.

부정
섭취하고나서 위염을 겪었다는 사례도 있어서 주의 필요.

I decided to spend a few hours researching the seemingly endless benefits of Agmatine Sulfate. Recently examine.com updated their dosage with a new study showing 2-3g/ day of Agmatine being effective in treating depression in 3 people. After complaining everywhere that the 500mg/day dose was too small to be effective, I'm proud to see my initial opinion be validated by science. I've been using for 6 months and it has cured my depression.

Promising results of Agmatine Sulfate:

Agmatine vs. anxiety/ depression:

• Source with three human subjects that were cured
• Rat study with stress induced anxiety and depression
• Agmatine ameliorates social isolation induced obsessive-compulsive behavior in mice
• Agmatinase, an inactivator of agmatine found upregulated in people with mood disorders
• Another rat study describing the potential mechanism for agmatine's anti-depressant effects
• Agmatine produces antidepressant-like effects by activating AMPA receptors and mTOR signaling

Agmatine - learning & memory:

• Agmatine impairs behavioral inferences in learning (this can be a good thing)
• Agmatine Improves Spatial Memory Consolidation: The Role of Nitric Oxide
• Agmatine Improves Learning and Memory in Alzheimer's Disease Model in Rats

Agmatine vs. autism:

• Decreased plasma agmatine levels in autistic subjects
• Agmatine rescues autistic behaviors in animal model

Agmatine vs. pain:

• 11 person study for neuropathic pain, shows improvement
• Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury
• 99 person study for neuropathic pain, shows difference from placebo

Agmatine & neuroprotection:

• Effect of agmatine against cell death induced by NMDA and glutamate in neurons and PC12 cells
• Agmatine protects the brain from drug-induced memory deterioration
• Agmatinergic system irregularities linked to CNS
• Agmatine attenuates reserpine-induced oral dyskinesia in mice
• There were a ton of neuroprotection studies, and studies surrounding cognitive decline but I don't feel like listing them all.

Agmatine vs. injury recovery:

• Rats heal faster after face is dissected
• Rats heal faster from eye injury

Agmatine long-term safety:

• Long-term (5 years), high daily dosage of dietary agmatine--evidence of safety: a case report
• Evidence for oral agmatine sulfate safety--a 95-day high dosage pilot study with rats

Functions of Agmatine Sulfate:

Agmatine and testosterone:

• https://pubmed.ncbi.nlm.nih.gov/7478229/

Agmatine and Serotonin function:

• https://pubmed.ncbi.nlm.nih.gov/19589348/
• Study suggesting the antidepressant effects of Agmatine are mediated by Serotonin
• Proof that Serotonin is not responsible for its antidepressant effects

Agmatine and NMDA antagonism/ glutamate action:

• https://pubmed.ncbi.nlm.nih.gov/15982768/
• https://pubmed.ncbi.nlm.nih.gov/9918557/

Agmatine and vasodilation (for muscle pump and, um, erections I suppose):

• https://pubmed.ncbi.nlm.nih.gov/7637544/

Agmatine is GABAergic and increases BDNF:

• https://www.nature.com/articles/tp2016116
• Brain-derived neurotrophic factor regulates the expression of D1 dopamine receptors

Agmatine Sulfate and tolerance:

• I will not be including any studies for this, as it's not typically relevant to nootropics